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By inhibiting the breakdown of stimulating neurotransmitters like norepinephrine and dopamine, Methylene Blue could cause feelings of anxiety, restlessness, or agitation in sensitive individuals, especially at higher doses

In animal studies, PPAR- agonists reduced IL-6 and TNF- expression in salivary glands while enhancing IL-4 production in serum, indicating a role in modulating the Th1/Th2 immune response balance [177]

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