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In the developed world, PEM more commonly occurs secondary to a chronic disease that interferes with nutrient metabolism, such as inflammatory bowel disease, chronic renal failure, or cancer (24)

This effect varies in different reagents

doi: 10.18240/ijo.2016.10.23

Tran HT, Blumenschein GR, Lu C, Meyers CA, Papadimitrakopoulou V, Fossella FV, Zinner R, Madden T, Smythe LG, Puduvalli VK, Munden R, Truong MT , Herbst RS

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194,195 mTORC2 also mediates Thr450 phosphorylation of AKT, which is independent of PI3K, occurs during AKT translation and contributes to AKT stability