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While O 2 released into the mitochondrial matrix is directly converted by SOD2 into the less reactive H 2 O 2 , O 2 released by the complex III into the mitochondrial intermembrane space can be exported via voltage-dependent anion channels (VDAC) into the cytosol followed by a SOD1-mediated conversion into H 2 O 2 [6, 7]

Mitochondrial dysfunction and insulin resistance: An update

Selected regions are labelled

Sachar, D

In other words, OXD/POD-like activity, which generates ROS and thereby inflicts oxidative damage on pathogens or cancer cells, has a beneficial therapeutic impact in the context of antimicrobial and antitumor treatments

A., Strubbe, S