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AI-driven analyses can uncover novel compounds and predict their senescence-modulating properties based on biological data.206 Moreover, systems biology approaches that analyze the complex networks of cellular aging processes could help uncover new targets for senomorphic therapies and optimize their clinical applications.207 Combination Therapies: Synergizing Senolytics and Senomorphics While both senolytics and senomorphics offer promising approaches for targeting cellular senescence, recent research suggests that combining these two therapeutic strategies may enhance their individual benefits, leading to more robust outcomes in promoting healthy aging

Therefore, these confounders must be strictly controlled during study so that the results across samples and studies can be comparable

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Biochim Biophys Acta 1830:32673288 Wu B, Dong D (2012) Human cytosolic glutathione transferases: structure, function, and drug discovery