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(More information) Several methodological issues (e.g., tests used to assess cognition, choice of study population, nature of the supplementation, study duration, etc.) may have contributed to the conflicting results observed in intervention studies

doi: 10.3390/PLANTS12040840 20

However, influenced by various signaling pathways, HSP70 upregulation is driven primarily by heat shock factors, particularly HSF1, which are involved in a complex regulatory network (Figure 2)

doi: 10.1016/j.chom.2016.07.001 86 ChenZXuQLiuYWeiYHeSLinWet al

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This not only impacts mental sharpness but also may contribute to other complications common in diabetes, such as heart and kidney disease