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Beyond drug sensitization, palmitoylation also intersects with the DDR, where loss of ZDHHC8 impairs G2/M checkpoint activation, inducing CIN and enhancing radiosensitivity [177]

Re-expressing cell lines of HMOX2 WT, HW/GW mutant, or K68R mutant were analyzed by immunofluorescence with anti-HA, anti-Calnexin, and anti-Tom20 antibodies to visualize the localization of HMOX2, ER, and mitochondria, respectively

Environ Chem Ecotoxicol 4:5066

Reactive oxygen species (ROS) production in normal cells, but especially in tumor cells, which have increased oxygen demand and utilization, is countered by generating an antioxidant defense state