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Methods: This retrospective cohort study used large epidemiological studies (Atherosclerosis Risk in Communities [ARIC], Cameron County Hispanic Cohort [CCHC], Hispanic Community Health Study/Study of Latinos [HCHS/SOL], Women's Health Initiative [WHI]) and electronic medical record-linked biobanks (BioVU, All of Us [AOU])

Comment What has been described as granular degeneration can be seen in combination with other forms of liver damage (e.g., necrosis, hydropic degeneration, inflammation) (Huang et al

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10.3390/ph18030410 18 De LucaP.CamaioniA.MarraP.SalzanoG.CarriereG.RicciardiL.et al (2022)

Although the clinical correlates of the cellular pathology in bipolar disorder await better characterization, there is little doubt that documented pathohistological changes in key cortico-limbic areas and the white-matter tracts play an important role in the clinical manifestations of bipolar illness