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A well-established mechanism by which AGEs promote oxidative stress involves binding to the receptor for AGEs (RAGE) and activation of intracellular signaling cascades including MAPK and NF-B, which upregulate pro-oxidant pathways such as NADPH oxidase and increase reactive oxygen species (ROS) generation 43,44,45,46

doi: 10.1038/nature03354

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Acetyl Tetrapeptide-3 hair-density peptide A targeted cosmetic peptide used in hair-density formulas

Bauweet al., 2010

Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation