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10.1016/j.foodchem.2013.05.122 Food Chem

SESN2 also decreases iron deposition and reverses the elevated expression of ACSL4 and TFR1 while enhancing the expression of SCL7A11 and GPX4, thereby inhibiting ferroptosis

Additionally, cyclin dependent kinases (CDKs) are also key regulators of DRR, which led to a phase I study examining the combination of ribocliclib, a CDK4/6 inhibitor, with carboplatin/paclitaxel in patients with recurrent platinum-sensitive ovarian cancer (NCT03056833) [85]

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Andrade F.H., Reid M.B., Allen D.G., Westerblad H

Its enzyme-targeted mechanism and reproducible activity make it a valuable compound for studying nicotinamide metabolism and methylation-related pathways.