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These changes are associated with increased antioxidant status, and detoxification of foreign compounds [9, 10, 3, 11]

Summary Diabetes doesnt only deplete GSH it impairs enzymes in the glutathione system (like glutathione synthetase, -glutamylcysteine synthetase, glutathione peroxidase)

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Biosynthetic pathways for histamine, gamma-aminobutyric acid (GABA), serotonin, and the catecholamines involve decarboxylation reactions that employ the coenzyme pyridoxal phosphate (PLP), a derivative of vitamin B6