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456 Inadequate oxygen supply in failing hearts shunts some free fatty acids into nonoxidative pathways, producing toxic lipids such as ceramides and diacylglycerol, which further damage mitochondrial function and exacerbate heart failure progression

10.1002/hep.27376 25 DeleveL

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Neuroimaging and pathological studies establish a correlation between Fe deposition in the SNpc and dopaminergic neuronal loss in PD patients 94,95 , indicating that disrupted Fe homeostasis represents a critical factor in PD neurodegeneration