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Among the most significantly enriched pathways, the PI3K/AKT pathway emerged as a central mediator of EW's protective effects, including attenuated brain damage, suppressed neuroinflammation, and reduced neuronal apoptosis [65]

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Roles of other tegument proteins in tegumentation processes have been reported one after another in KSHV as well as related gamma-herpesviruses such as MHV-68

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By effectively reducing viral load and inhibiting virus entry into host cells, the following inflammatory response, injury to the endothelium, and initiation of coagulation will subsequently diminish, leading to the reduced COVID-19 associated complications, especially the occurrence of thrombosis (Figure 3)