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Mu-opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling

491 CRS prevention can be accomplished by inhibiting the IL-6 receptor using tocilizumab (an IL-6 receptor antagonist) or through monocyte depletion

When three different extracts (methanolic extract, butanol fraction, aqueous fraction) of black maca and yellow maca were compared to control their effects on sperm parameters in adult mice, both black and yellow maca were found to increase daily sperm count differentially, depending on the administered format [34]

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Similarly, pregnant or breastfeeding individuals should avoid use given unknown effects on fetal development