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Detailed statistical values are provided in Supplementary Table 7

Interestingly, the reversal of the FXN gene silencing in neurons derived from patient iPSCs is comparable to that found in previous studies performed on PBMCs and in vivo models [55,56,57,58]

MOTS-c optimizes mitochondrial function and metabolic efficiency through AMPK activation, improved insulin sensitivity, and support for mitochondrial biogenesis