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For the rats administered either curcumin (25 or 50 mg/kg) or a combination of curcumin (25 mg/kg) with piperine (2.5 mg/kg) once daily for 21 consecutive days prior to 3-Nitropropionic acid administration (3-NP, a neurotoxin inducing symptoms of Huntingtons disease), it was found that both curcumin monotherapy and the curcumin-piperine combination demonstrated protective effects against 3-NP-induced motor deficit, biochemical alterations and neurochemical abnormalities

The VEGF family includes VEGF subtypes A-E and placental growth factor, among which VEGF-A plays a major role in the regulation of angiogenesis (30)

Reduction of the periplasmic disulfide bond isomerase, DsbC, occurs by passage of electrons from cytoplasmic thioredoxin

Statistical significance was determined by two-sided Students t-tests

Rahman et al., 2024)

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