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Molecules 24:2030 Koudelka S, Turanek Knotigova P, Masek J, Prochazka L, Lukac R, Miller AD, Turanek J (2015) Liposomal delivery systems for anti-cancer analogues of vitamin E

To every mentor who has invested in me, challenged me, believed in me, and encouraged me to chase goals bigger than I ever imagined, thank you for seeing something in me and reminding me that amazing things are possible

It can be seen that the inhibition of GPX4, the depletion of glutathione and the increase of lipoxygenase activity promote the accumulation of polyunsaturated fatty acids and the production of fatty acid-free radicals, thereby inducing the occurrence of cell ferroptosis, cause tissue damage, and further aggravate pathological processes including diabetes, periventricular leukomalacia, acute kidney disease, cancer, and other diseases (Otasevic et al., 2021)

Existing drugs lack precision in targeting specific tissues

Toso, J

Polydorou, C., Mpekris, F., Papageorgis, P., Voutouri, C., & Stylianopoulos, T