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Medications that are irritating when injected subcutaneously and are absorbed slowly can be injected intramuscularly

It enhances bioavailability by employing mitochondrial approaches such as triphenylphosphonium (TPP) modification, consequently amplifying its antioxidant and anti-apoptotic properties (160, 161)

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Additionally, mitochondria are able to activate different intracellular signaling pathways necessary to defend the host against pathogens such as the mitochondrial anti-viral signaling (MAVS) and activation of the nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLRP3) inflammasome by mitochondrial DNA (mtDNA) (Zhong et al., 2018)