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Compared with Control cells, p53 KO cells exhibited far fewer nutlin-3induced changes in gene expression, consistent with most changes observed in Control cells being p53-dependent (Fig 3A)

More critically, SLC25A39 deficiency promoted cytochrome c release and activated the caspase cascade, ultimately triggering apoptosis of HCC cells

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J Pharmacol Exp Ther 341:274284

Although FMT has also been attempted in CD and refractory IBD, reports on its efficacy have been inconsistent [428], These discrepancies may be attributed to factors such as disease heterogeneity, donor selection, and transplant protocols