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Upon activation, Nrf2 translocates to the nucleus, binds specifically to the Antioxidant Response Element (ARE) and induces transcription of downstream genes (Baird and Dinkova-Kostova, 2011) (Figure 2B)

Williams, K

Blood 130(10):12091212 Choi R, Lee MN, Kim K, Baek SY, Kim TJ, Hong SN et al (2020) Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohns disease

Fasting state, normal gastric emptying, alkaline small intestine pH

Due to its lipophilic nature, NFPS tends to accumulate within the plasma membrane, diffusing through the lipid bilayer until it reaches GlyT1

Reactions of the melatonin metabolite AMK (N1-acetyl-5-methoxykynuramine) with reactive nitrogen species: formation of novel compounds, 3-acetamidomethyl-6-methoxycinnolinone and 3-nitro-AMK