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Additionally, carbon units for the folate cycle can also be derived from formate, which can donate one carbon directly to tetrahydrofolate in a reversible reaction catalyzed by the tri-enzyme Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase, and Formyltetrahydrofolate Synthetase 1 (MTHFD1)

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Ethics declarations Competing interests The authors declare no conflict of interest

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved

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Tosatto SCE, Bosello V, Fogolari F et al (2008) The catalytic site of glutathione peroxidases