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The landmark DSIP sleep study used 25 nmol/kg IV for 7 consecutive nights , measured via polysomnography

PubMed Central, Ferrarotti, Ilaria, et al

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10.1126/science.276.5309.122 Summary Keywords busulfan, population pharmacokinetics, glutathione S-transferase activity, precision dosing, pediatric transplantation, virtual clinical trial Citation Cao D, Qian X, Wang P, Zheng X, Huang S, Wei Z, Jiang W, Yu L, Jiang X, Yu Y, Mao J and Zhai X (2025) Semi-mechanistic population pharmacokinetic model incorporating glutathione S-transferase activity for personalized busulfan dosing in pediatric allogeneic hematopoietic cell transplantation

EGCG may also reduce appetite by influencing gut hormones associated with food intake, supporting weight loss efforts [44,45]