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This link was reported using rat liver (Veech et al., 1969), which was also found following long-term DR in mice, where DR increased the hepatic cytoplasmic [NADPH]/[NADP + ] as inferred from changes in the malate/pyruvate, and reduced the hepatic cytoplasmic [NAD + ]/[NADH] as evidenced from changes in the pyruvate/lactate (Table 1

Answer: When administered by trained clinicians, IV nutrient therapy is generally considered safe and can be used alongside conventional treatments