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shRNA against mouse Sirt7 -1, 5-TGCATCCCTAACAGAGAGTAT-3

Compound 109/RG2833 is currently further engineered to improve its brain distribution and metabolic stability [123]

Subsequently, 13 C-CO 2 values of the samples were analyzed using a GC (HP 6890 N, Agilent Technologies) coupled with a Delta PLUS XL IRMS (ThermoQuest Finnigan), similar to the method previously employed (Schroll et al., 2020)