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COJEC drugs: cisplatin (Santa Cruz Biotechnology, sc-200896), vincristine (Santa Cruz Biotechnology, sc-201434), etoposide (Santa Cruz Biotechnology, sc-3512), cyclophosphamide (Santa Cruz Biotechnology, sc-361165), and carboplatin (Santa Cruz Biotechnology, sc-202093A)

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Pro-inflammatory stimuli induce the activation of specific pathways through the stabilization of transcription factors such as nuclear factor (NF)-B and hypoxia-inducible factor (HIF)-1, which trigger the expression of markers like inducible nitric oxide synthase (iNOS), CD80, and CD86 and the release of tumor necrosis factor (TNF)-, IL-1, IL-6, IL-12, and IL-23

There are genetic variants that impact glutamate levels a bit, but overall, glutamate levels are tightly controlled by multiple pathways

Alves DR, Maia de Morais S, Tomiotto-Pellissier F, Miranda-Sapla MM, Vasconcelos FR, da Silva ING, Araujo de Sousa H, Assolini JP, Conchon-Costa I, Pavanelli WR, Freire F (2017) Flavonoid composition and biological activities of ethanol extracts of Caryocar coriaceum Wittm., a native plant from Caatinga Biome