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The concept of glutathione as an essential guardian for cellular protection from oxidative stress and xenobiotic toxicity has spurred a large number of clinical studies using NAC in different chronic disease conditions (Sies, 1999

[Epub ahead of print] [DOI] [PubMed] [Google Scholar] Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO