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Furthermore, the activation of the PI3K/Akt signaling pathway in macrophages during gouty arthritis studies has been found to induce an anti-inflammatory effect by promoting a shift toward the M2 macrophages, ultimately mitigating MSU-induced gouty arthritis (76)

Our findings are consistent with prior observations showing that C/EBP expression is elevated in fatty liver conditions and that its activation enhances the transcription of lipogenic genes such as SREBP-1c and FASN 32,33

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In a mouse model of Fabry disease, acetyl-l-carnitine caused analgesia by up-regulating type-2 mGlu receptors

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