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It is possible that the elevated serotonin concentrations in the plasma originate from platelets as either a cause or consequence of prothrombotic propensity (direct systemic administration of CB in mice has demonstrated to increase prothrombotic activity) [59]

382 As a central node in energy sensing and metabolic regulation, the activation of AMPK helps maintain cellular energy balance and prevents cell death due to energy depletion

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Besides having a substantial regenerative effect on distressed mucosal barriers, it also acts as a major source of energy for proliferation and differentiation of intestinal epithelial cells

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