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Elevated cortisol levels can downregulate BDNF expression through various mechanisms, including the inhibition of CREB activity and increased expression of inhibitory factors (Naveen et al

Endoplasmic reticulum stress (ERS) has been identified as a major contributor to human diseases, including DM, neurodegenerative disorders, and cancer (Hetz and Papa, 2018)

S., Seiwerth, S., Rucman, R., Turkovic, B., Rokotov, D

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406 It was also proved that downregulation of Mfn2 occurs in conditions such as liver cancer, non-alcoholic steatohepatitis, and liver fibrosis