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There was no blinding, there was no control group, and there were no validated questionnaires

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As rehabilitation progresses and active training resumes (typically 8-12 weeks post-surgery depending on the procedure), the protocol transitions to maintenance dosing with cryotherapy reserved for higher-intensity training days

The mechanisms sustaining this heterogeneity are unknown, although it should be acknowledged that CVOTs lack the statistical power to reliably detect differences in specific MACE components

Controlled human data is more limited, which is why it remains a research-use compound in most jurisdictions the gap between animal and human evidence is its most-cited limitation

M.ZhuM.et al