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Description

Total glutathione values (BSO did not cause oxidation of glutathione, data not shown)

Myers GL, Miller WG, Coresh J, Fleming J, Greenberg N, Greene T, et al

Iannacci, et.al., 2025)

Telcyta (TLK286) is a GSH analogue that, when metabolized by GSTP1-1, releases a reactive tetrakis (chloroethyl) phosphorodiamidate fragment and a glutathione analogue vinyl sulphone that, following activation, triggers the stress response pathway, leading to cellular apoptosis induction [69]

Inadequate function of methionine synthase can lead to an accumulation of homocysteine, which has been associated with increased risk of cardiovascular disease and age-related neurodegenerative disease (e.g., Alzheimers disease)