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Furthermore, numerous effective small molecules targeting NRF2, an important transcription factor that regulates antioxidant genes, have been developed and show promising therapeutic effects in multiple diseases

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Most active research clusters in Philadelphia (2,072 recruiting) and Pittsburgh (1,325 recruiting), but the state has 171 cities running research sites, with smaller concentrations in Hershey (289), Danville (141), Allentown (134), Bethlehem (108), and plenty of others

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By improving mitochondrial efficiency and promoting lipid metabolism, ALA helps the liver break down and mobilize stored fats, reducing hepatic fat accumulation and inflammation