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ROS directly and indirectly contribute to stellate cell activation and to chronic inflammatory response with up-regulation of proinflammatory cytokines (TNF-, IL-6, and IL-1), apoptosis, and development of hepatic fibrosis [(Figure 1]

Given that routine respiration was comparable between both cell types, the data suggest that reduced incorporation of glucose-derived carbons into the TCA cycle is likely due to the increasing reliance on alternative substrates such as fatty acids or glutamine [58, 59]

erinaceus was administered daily for a minimum of 9 days and up to 13 weeks, with most studies using a 30-day administration timeline

Small hairpin RNA targeting inhibition of NF-B gene in endometriosis therapy of Macaca fascicularis

Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study

TrappoliereMCaligiuriASchmidMBertolaniCFailliPVizzuttiFet al