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All three elephants had a history of EEHV detection and pre-existing humoral immunity, consistent with latent infection in adult animals prior to the study 42

Therefore, we recommend that when deciding on the use of high-dose antineoplastic combination therapy to prolong survival of patients having persistent and resistant GBM tumors, the long-term effects of this treatment on cross-resistance and MDR phenotype should be analyzed in primary cell cultures obtained from patients