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Wolstenholme and Gardner 1950)

10.1016/j.biocon.2016.07.013 81 GomaaM

This isn't speculative: radioligand binding assays conducted on human tissue samples show MC4R availability drops by approximately 35% during morning hours (6 AM12 PM) compared to evening baselines

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Additionally, it is subject to limited absorption by the small intestine and fast elimination by the gallbladder and its oral bioavailability is minimal