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In-vitro fibroblast studies indicate that GHK-Cu upregulates transcription of collagen and elastin genes and supplies copper as a cofactor for lysyl oxidase, the enzyme that cross-links these matrix proteins

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The typical patient has a soft-tissue injury that stalled: they completed physical therapy, have no surgical indication, but are still symptomatic at 8 to 12 weeks

The rationale for titrating upward over time, rather than starting at the target dose, mirrors the approach taken with other metabolic peptides: the goal is to identify the minimum effective dose for each individual while monitoring for tolerability