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5 Chronic inflammation due to gut microbial disorders contributes to Mets Gut microbes play a key role in maintaining physiological functions as they regulate host nutrition, energy harvesting, epithelial homeostasis, immune system, and drug metabolism while maintaining homeostasis ( Figure 3 )

It has been concluded that melatonin acts as the most versatile biological signal mediating the inter-organ communication between the gut and the liver (14, 15) METABOLISM OF MT Circulating MT is metabolized mainly in the liver through two major steps

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Thus cows must continuously divert energy and nutrients from other bodily functions to maintain rumen homeostasis

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In most proteins which consist of more than one polypeptide chain, the chain are kept together by interchain disulfide bridges