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2010), however, no information on dropout or loss to follow-up was provided

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In fact, the S1 subunit alone was observed to induce an increased production of IL-6 and activation of NF-B and in consequence, inflammation in endothelial cells (334), and circulating S1 induced the expression of TLR2, TLR4, NLRP3, IL-1, TNF and HMGB1 in rats at 24 h after treatment, and TLR2, TLR4, NLRP3 and IL-1 remained overexpressed even after seven days (335)

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Essential for the diagnosis of depressive illness due to a medical condition is the existence of a temporal association between the onset, exacerbation, or remission of the general medical condition and the mood disturbance