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For clinical translation, non-invasive alternatives (e.g., intranasal NSC-derived exosomes, focused ultrasound-enhanced IV delivery) should be prioritized, as pioneered in recent ASD trials using intranasal routes [37, 38]

Clinically Proven Safety Profile 1) Advantages: - Supported by clinical studies demonstrating low irritation (ideal for post-procedure skin)

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Moreover, many tumors including PCa cells shed DNA into the serum or other easily accessible body fluids (e.g., semen, urine), simplifying the detection of GSTP1 epimutations in early tumorigenesis stages

Systematic reviews show positive results for chronic tendinopathy (especially lateral epicondylitis and patellar tendinopathy) and knee osteoarthritis