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In contrast, the oral CoQ10 group showed only slight improvements during the same period

The dysregulated secretion of adipokines leads to insulin resistance and increased inflammation (406), while the intricate interplay between AT and the immune system becomes crucial in age-related metabolic decline, mirroring patterns observed in obesity (425)

Oxidative stress plays a crucial role in the development of age-related diseases including arthritis, diabetes, dementia, cancer, atherosclerosis, vascular diseases, obesity, osteoporosis, and metabolic syndromes (Tan et al., 2015a

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We observed that the upregulated DEPs were mainly enriched in cytoskeleton and intercellular connectivity signaling pathways after CD5/ LNP-FAPCAR 2.2 treatment, all of which were related to cell polarization (Fig