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The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis

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The former mechanism is preferred because RS scavengers can be consumed during the reaction and may generate toxic radicals derived from the chelators ( One of the first chelating agents documented to reduce RS production (specifically the hydroxyl radical) in vitro was diethylenetriaminepentaacetic acid (DTPA)

The steady-state concentration of GSH remains relatively stable between S = 1.4 and S = 2, corresponding to increases in stimulation ranging from 40% to 100% compared to males

This effect may also depend on the GSH-induced inhibition of various respiratory viruses replication, an effect which is thought to prevent increased viral loads and the subsequent massive release of inflammatory cells into the lung

Table EV2)