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In accordance with CR being a product of the PPP (Figure 4), we found that CR hi tumors were also enriched for the pentose interconversion pathway, with the core enriched genes including the PPP enzyme genes RPE and XYLB and the genes in the UGT family of enzymes, including UGT1A8 , UGT1A3 , and UGDH (Figure 5B and Supplemental Figure 4E)