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Recent human studies have highlighted presence of bioenergetic maladaptation in brains in aging and neurodegenerative disorders, including PD [4, 5]

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Daily intraperitoneal injection of VGB4 at different doses (0.25, 1, 2.5, 5 and 10 mg/kg) or scr (10 mg/kg) was administrated for treated groups whereas the control group received the equal volume of PBS for two weeks