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Moreover, the complexity of the cell composition of this tissue and the elevated oxygen levels corroborate to elevated capacity of the CNS in ROS production

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After consideration of public comments, we are increasing both our one-time and ongoing annual burden estimates as demonstrated in section XXIII

185 GM-CSF derived from breast cancer tumor cells can promote ARG1 expression in tumor-infiltrating myeloid cells through STAT3 and p38 MAPK signaling pathways, enhance the function of tumor-infiltrating myeloid cells, and promote the development of immunosuppressive TME (Fig