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reported that CB-839 could promote the production of reactive oxygen species (ROS) in colorectal cancer cells, cause nuclear translocation of Nrf2, and subsequently upregulate the expression of uridine phosphorylase 1 (UPP1), which promotes the activation of 5-fluorouracil (5-FU)

The hepatic metabolism of ethanol exhibits saturation kinetics, which makes it extremely sensitive to variations in the gastric emptying rate (81, 93)

Since both pancreas and liver are embryologically related, there is a definite potential for metaplasia

Measurement of single-myocyte excitability, contractility, and Ca 2+ transients Myocytes were enzymatically isolated as described previously ( 2+ transients (loaded with FURA-2AM)

Werner syndrome (WS), which is distinguished by severe metabolic dysfunction, dyslipidemia, early atherosclerosis, and insulin resistance diabetes, is thought to most closely mimic normal aging