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The primary cause of glucotoxicity is insulin resistance, which arises from defective islet cell function and damage caused by reduced insulin mRNA expression, associated with diminished transcription or activity of transcription factors involved in insulin production (Mota et al., 2016)

Relying on objective data prevents the guesswork and ensures that your interventions are clinically appropriate

doi: 10.1016/j.imbio.2015.06.004 100 McNabneySMHenaganTM

L., Rowe P

2008 October 22 (10):3607-16

Access this article Similar content being viewed by others Data availability All data generated and analyzed during this study are available from the corresponding author on reasonable request