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The subjects were young (average age 27), lean (average body mass index 24), and physically fit

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Therefore, by targeting the expression of the non-Smad signaling pathway RAS/rapidly accelerated fibrosarcoma (RAF)/FOXO signaling cascade and its downstream inflammatory factors TNF- and IL-1, AS-IV markedly inhibits the transdifferentiation of fibroblasts and alleviates LPS and cigarette smoke treatment-induced COPD-related EMT progression

H.MullerY

FEBS Letters 584, 889897

Amplification of the c- MET gene, with consequent protein overexpression and constitutive kinase activation, has been reported in a number of human primary tumors