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I would like to see rigorous clinical trials before approval

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Contraindications Increased sensitivity to any component of the medication

The challenge of co-encapsulating hydrophobic and hydrophilic drugs in a single nanoparticle with controlled release should be investigated, as this strategy addresses the difficulties associated with delivering structurally dissimilar drugs

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This represents a significant limitation in the evidence base, as large-scale human trials examining musculoskeletal applications have not been published