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Delves P, Roitt I

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Clinicians have reported cases of tramadol-induced mania in patients without a prior history of bipolar disorder (61)

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Here, we will review the pathologic mechanisms of these diseases, and discuss the molecular and cellular mechanisms of AST activity that has been reported in in vitro, in vivo, and clinical trials

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PMID: 15275737

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16 , 637647.e13 (2018)

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In addition to the findings with ASMase knockout mice, which models the lysosomal storage disorder NiemannPick type A disease, inhibition of glucocerebrosidase in hepatocytes by conduritol -epoxide, a cellular model of Gaucher disease that exhibits lysosomal cholesterol accumulation sensitizes to APAP-induced cell death (Teratani et al., 2017)

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