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Data acquisition and analysis were performed using WinLTP

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Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IB kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3- thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation

doi: 10.1016/j.neuron.2019.12.007 118 UllandTKSongWMHuangSCUlrichJDSergushichevABeattyWLet al

For this pupose isolation and identification of target protein(s) for the bioactive compound are essential in understanding its function fully

Histological assessments showed that Lv-siPDE5-ADSC treatment resulted in higher smooth muscle content and improved cavernous tissue recovery, with significantly enhanced smooth muscle/collagen ratios compared to unmodified ADSCs