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Brucein D, a naturally occurring quassinoid, enhances the sensitivity of pancreatic ductal adenocarcinoma (PDAC) cells to gemcitabine (GEM) by promoting the ubiquitin-proteasome-dependent degradation of NRF2 and suppression of the NRF2 signaling pathway [104]

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miR-9-5p is involved in the rescue of stress-dependent dendritic shortening of hippocampal pyramidal neurons induced by acute antidepressant treatment with ketamine

To address these issues, researchers have proposed various enhancements, such as introducing symmetry in adversarial training and refining loss functions to stabilize learning and improve sample diversity [79]

With decades of expertise in diabetes and metabolic disorders, the company turned its innovation engine toward tackling obesity